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Updated: Jan 23, 2026

Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein
Published on: March 16, 2022
Put the Pedal to the METTL1: Adding Internal m7G Increases mRNA Translation Efficiency and Augments miRNA Processing
Konstantinos Boulias1, Eric Lieberman Greer2
1Division of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Abstract:
Complementary papers by Zhang, Liu, and colleagues (Zhang et al., 2019) and Pandolfini, Barbieri, and colleagues (Pandolfini et al., 2019) develop new sequencing techniques that reveal that METTL1 N7-methylates internal guanosines in mRNAs and miRNAs to increase translation efficiency and miRNA processing, respectively.
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