Testing developmental toxicity in a second species: are the differences due to species or replication error?

Hedwig M Braakhuis1, Peter T Theunissen2, Wout Slob3

  • 1Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

Summary

Study findings indicate that variability in developmental toxicity study results between rats and rabbits may stem from study errors, not species differences. This suggests the necessity of a second species study may be questionable for chemical and pharmaceutical safety assessments.

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