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Assembly of α-synuclein aggregates on phospholipid bilayers

Zhengjian Lv1, Mohtadin Hashemi2, Siddhartha Banerjee2

  • 1Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025, United States of America; Bruker Nano Surfaces Division, 112 Robin Hill Road, Goleta, Santa Barbara, CA 93117, United States of America.

Biochimica Et Biophysica Acta. Proteins and Proteomics
|June 22, 2019
PubMed
Summary

Phospholipid bilayers accelerate alpha-synuclein (α-syn) aggregation, a key process in Parkinson's disease. This membrane-initiated assembly, especially on POPS lipids, offers insights into pathological protein formation.

Keywords:
Amyloid aggregationComputer modelingLipid bilayerParkinson's diseaseTime-lapse AFMα-synuclein

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