Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tree of Life - Bacteria, Archaea, Eukaryotes02:40

The Tree of Life - Bacteria, Archaea, Eukaryotes

38.0K
The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
38.0K
Other Unique Bacteria01:18

Other Unique Bacteria

426
Magnetic bacteria exhibit a directed movement called magnetotaxis, driven by structures called magnetosomes. These magnetosomes consist of chains of magnetic particles made of either magnetite (Fe₃O₄) or greigite (Fe₃S₄) and are organized in a linear conformation by a protein scaffold within invaginations of the cell membrane. The bacteria align along the north–south magnetic field lines, much like a compass needle. They are typically microaerophilic or anaerobic...
426
The Roles of Bacteria and Fungi in Plant Nutrition02:11

The Roles of Bacteria and Fungi in Plant Nutrition

47.2K
Plants have the impressive ability to create their own food through photosynthesis. However, plants often require assistance from organisms in the soil to acquire the nutrients they need to function correctly. Both bacteria and fungi have evolved symbiotic relationships with plants that help the species to thrive in a wide variety of environments.
47.2K
Biosynthesis in Bacteria01:24

Biosynthesis in Bacteria

593
Biosynthesis in bacteria is a fundamental anabolic process that generates essential macromolecules, including proteins, nucleic acids, lipids, and polysaccharides. These macromolecules are critical for cellular growth, replication, and function. The process is tightly regulated and energetically linked to catabolic pathways to ensure optimal resource utilization.Biosynthetic pathways begin with precursor metabolites such as pyruvate, acetyl-CoA, and glucose-6-phosphate derived from glycolysis,...
593
Hyperthermophilic Bacteria01:21

Hyperthermophilic Bacteria

513
Domain Bacteria includes some unique hyperthermophilic species. They exhibit remarkable adaptations that enable survival in extreme environments.Thermotoga species are rod-shaped, gram-negative, non-sporulating hyperthermophiles that form a sheath-like envelope called a toga. They ferment sugars or starch, producing lactate, acetate, CO₂, and H₂, and can also grow via anaerobic respiration using H₂ and ferric iron. Found in hot springs and hydrothermal vents, over 20% of their...
513
Anoxygenic Phototrophic Bacteria01:28

Anoxygenic Phototrophic Bacteria

807
Anoxygenic phototrophic bacteria are a diverse group of microorganisms that perform photosynthesis without producing oxygen. They primarily include purple sulfur bacteria, purple nonsulfur bacteria, green sulfur bacteria, and green nonsulfur bacteria. These bacteria are classified into the Gammaproteobacteria, Alphaproteobacteria, Betaproteobacteria, Chlorobi, and Chloroflexi lineages, each with distinct physiological and ecological adaptations.Purple sulfur bacteria belong to the...
807

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Sequence-Based Update on Amino Acid Substitutions in Influenza Polymerase Acidic Protein in Europe That Alter Baloxavir Susceptibility From 2009 to 2025.

Influenza and other respiratory viruses·2026
Same author

Serum Short-Chain Fatty Acids in Colorectal Cancer: Diagnostic Performance and Decoupling from Gut Producer Abundance.

Cells·2026
Same author

Non-canonical STING activation by calcium influx paired to endoplasmic reticulum stress.

Cell communication and signaling : CCS·2026
Same author

Divergent macrophage responses to Influenza A virus and <i>Streptococcus pneumoniae</i>: co-infection drives bacterial dominance whereas superinfection favors viral priming.

Frontiers in immunology·2026
Same author

STING activation by teniposide: a potential direct mechanism beyond cGAS stimulation.

Frontiers in immunology·2026
Same author

Disease modulation by TIV vaccination during secondary pneumococcal infections in influenza-infected mice.

Journal of virology·2025

Related Experiment Video

Updated: Jan 23, 2026

Ex Vivo Infection of Live Tissue with Oncolytic Viruses
12:08

Ex Vivo Infection of Live Tissue with Oncolytic Viruses

Published on: June 25, 2011

13.2K

Oncolytic bacteria: past, present and future.

Sergio Rius-Rocabert1, Francisco Llinares Pinel1, Maria Jose Pozuelo1

  • 1Microbiology Section, Pharmaceutical and Health Science Department. Faculty of Pharmacy. Instituto de Medicina Molecular Aplicada (IMMA). San Pablo-CEU University. CEU Universities, Campus Montepríncipe. Boadilla del Monte, E-28668 Madrid, Spain.

FEMS Microbiology Letters
|June 22, 2019
PubMed
Summary
This summary is machine-generated.

Bacteria can be used to selectively infect tumors, triggering an immune response for cancer treatment. This review revisits historical oncolytic bacteria use and discusses future perspectives for improved cancer immunotherapy.

Keywords:
bacteria recognitioncancercancer therapyclinical trials in cancerinnate immune responseoncolytic bacteria

More Related Videos

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats
08:55

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Published on: April 15, 2016

9.9K
Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy
08:51

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

9.5K

Related Experiment Videos

Last Updated: Jan 23, 2026

Ex Vivo Infection of Live Tissue with Oncolytic Viruses
12:08

Ex Vivo Infection of Live Tissue with Oncolytic Viruses

Published on: June 25, 2011

13.2K
Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats
08:55

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Published on: April 15, 2016

9.9K
Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy
08:51

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

9.5K

Area of Science:

  • Oncology
  • Immunology
  • Microbiology

Background:

  • The concept of using bacteria to treat cancer dates back over a century.
  • William Coley pioneered early immune-therapy using bacteria for tumor treatment.
  • Bacteria-induced immune responses can lead to tumor rejection and long-term protection.

Purpose of the Study:

  • To review the historical development of oncolytic bacteria as cancer therapy.
  • To explore the mechanisms of bacterial oncolysis, including direct tumor toxicity and immune activation.
  • To discuss current clinical trials and future perspectives for bacterial cancer treatment.

Main Methods:

  • Historical literature review of oncolytic bacteria research.
  • Analysis of scientific publications on bacterial mechanisms against tumors.
  • Examination of data from preclinical models and clinical trials.

Main Results:

  • Bacteria can selectively target and infect tumor cells.
  • Bacterial components activate innate immune responses against tumors.
  • Immune activation by oncolytic bacteria can lead to tumor rejection and sustained anti-tumor immunity.

Conclusions:

  • Oncolytic bacteria represent a promising strategy for cancer immunotherapy.
  • Understanding bacterial mechanisms and host immune responses is crucial for optimizing therapy.
  • Future research should focus on enhancing bacterial efficacy and safety for clinical application.