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Static perimetry in canthaxanthin maculopathy.

C Harnois1, P Cortin, J Samson

  • 1Department of Ophthalmology, Laval University Medical Center, Quebec, Canada.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|January 1, 1988
PubMed
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Canthaxanthin retinopathy can impair vision. Patients with maculopathy showed reduced retinal sensitivity, suggesting adverse effects on the neurosensory retina even after discontinuing the supplement.

Area of Science:

  • Ophthalmology
  • Toxicology
  • Neuroscience

Background:

  • Canthaxanthin is a carotenoid used as a dietary supplement and colorant.
  • Ocular toxicity, including maculopathy, has been associated with high-dose or long-term canthaxanthin ingestion.
  • The impact of canthaxanthin retinopathy on retinal function requires further investigation.

Purpose of the Study:

  • To evaluate the long-term effects of canthaxanthin ingestion on retinal sensitivity.
  • To determine if canthaxanthin retinopathy causes persistent neurosensory deficits.
  • To compare retinal sensitivity in patients with and without canthaxanthin-induced maculopathy.

Main Methods:

  • Threshold static perimetry was conducted on 19 patients with a history of canthaxanthin ingestion (11 with maculopathy, 8 without).

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  • A control group of patients with no history of canthaxanthin ingestion was included.
  • Perimetry was repeated 2-3 years after cessation of canthaxanthin intake.

    • Main Results:

    • Patients with canthaxanthin maculopathy consistently demonstrated lower retinal sensitivity compared to controls.
    • Patients who ingested canthaxanthin but did not develop maculopathy showed no significant difference in retinal sensitivity from controls.
    • Visual acuity remained 6/9 or better in all study participants.

    Conclusions:

    • Canthaxanthin retinopathy can lead to persistent reductions in retinal sensitivity.
    • These findings suggest that canthaxanthin-induced retinopathy adversely affects the neurosensory retina.
    • Long-term visual function may be compromised in individuals with a history of canthaxanthin maculopathy.