Hydroxypropyl-β-cyclodextrin-based fast dissolving carbamazepine printlets prepared by semisolid extrusion 3D...

Area of Science:

• Pharmaceutical Technology
• Materials Science

Background:

• Poorly soluble drugs like carbamazepine require precise dosing and rapid release.
• Traditional formulations often face challenges in achieving these requirements.

Purpose of the Study:

• To explore the use of cyclodextrins for 3D printing poorly soluble drugs.
• To develop orodispersible and immediate-release printlets with tunable drug release.

Main Methods:

• Utilized semisolid extrusion-based 3D printing with hydroxypropyl-β-cyclodextrin (HPβCD) and cellulose ethers.
• Assessed rheology for printable compositions and evaluated printlet robustness (weight, dimensions, hardness, drug content).
• Characterized drug crystallinity, disintegration, and dissolution profiles.

Main Results:

• HPβCD is a feasible excipient for 3D printing poorly soluble drugs.
• Drug release profiles can be tuned by altering cellulose ethers.
• Semisolid extrusion successfully formed carbamazepine-HPβCD complexes in situ.

Conclusions:

• 3D printing via semisolid extrusion is a viable method for producing printlets with desirable physical and drug release properties.
• This technology offers a promising approach for formulating poorly soluble drugs requiring adjusted dosage and rapid release.