A 29 kDa GTP-binding protein expressed in mouse brain, lung, kidney, spleen and transformed NIH3T3 cells

A novel 29 kDa GTP-binding protein has been detected in mouse brain, kidney, lung and spleen. The binding property is specific for guanine nucleotides, and the binding activity for GTP is retained after transfer of the 29 kDa protein to a nitrocellulose membrane. The 29 kDa protein is also expressed in NIH3T3 cells transformed by activated human c-Ha-ras, hst, ret and c-raf. The 29 kDa protein present constitutively in some mouse tissues is possibly involved in some cellular signal transduction relevant to the function of these tissues. In addition, its function may play a role in phenotype of transformed cells.