Related Experiment Video

Updated: Jan 23, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

9.6K

Interrogation of the infarcted and salvaged myocardium using multi-parametric mapping cardiovascular magnetic

Derek J Hausenloy1,2,3,4,5,6, Mei Xing Lim4,5, Mervyn H H Chan4,5

  • 1The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, London, United Kingdom.

Scientific Reports
|June 23, 2019
PubMed

Insights

Cardiovascular magnetic resonance (CMR) mapping using extracellular volume fraction (ECV) effectively differentiates infarcted from salvaged myocardium after ST-segment elevation myocardial infarction (STEMI). Native T1 and T2 mapping showed limitations in this distinction.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • ST-segment elevation myocardial infarction (STEMI) causes significant myocardial damage.
  • Accurate assessment of infarct core and salvaged myocardium is crucial for patient management.
  • Cardiovascular magnetic resonance (CMR) is a key imaging modality for evaluating myocardial infarction.

Purpose of the Study:

  • To evaluate the utility of multi-parametric CMR mapping in differentiating infarcted from salvaged myocardium post-STEMI.
  • To compare the performance of native T1, T2 mapping, and extracellular volume fraction (ECV) in this context.

Main Methods:

  • Forty-eight STEMI patients underwent CMR 4±2 days post-infarction.
  • Analysis included native T1 maps, T2 maps, late gadolinium enhancement (LGE), and automated ECV maps.
  • Regions of interest were defined in infarcted, salvaged, and remote myocardium.

Main Results:

  • T1, T2, and ECV were elevated in both infarcted and salvaged myocardium compared to remote myocardium.
  • Native T1 and T2 mapping could not distinguish between infarcted and salvaged myocardium.
  • ECV was significantly higher in the infarcted myocardium compared to the salvaged myocardium.

Conclusions:

  • Extracellular volume fraction (ECV) mapping is superior to native T1 and T2 mapping for differentiating infarcted from salvaged myocardium after STEMI.
  • ECV provides valuable insights into tissue characterization in the post-STEMI setting.
  • These findings have implications for refining CMR-based assessment of myocardial infarction outcomes.

More Related Videos

Acute Myocardial Infarction in Rats07:45

Acute Myocardial Infarction in Rats

Published on: February 16, 2011

54.5K
Myocardial Infarction and Functional Outcome Assessment in Pigs12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

28.6K

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
9.2K
Atomic Nuclei: Magnetic Resonance01:05

Atomic Nuclei: Magnetic Resonance

The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
1.2K
Freezing Point Depression and Boiling Point Elevation03:12

Freezing Point Depression and Boiling Point Elevation

Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
39.7K
Nuclear Magnetic Resonance (NMR): Overview01:07

Nuclear Magnetic Resonance (NMR): Overview

Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
6.8K
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
231
Resonance02:52

Resonance

The Lewis structure of a nitrite anion (NO2−) may actually be drawn in two different ways, distinguished by the locations of the N-O and N=O bonds.
64.8K