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Related Experiment Video

Updated: Jan 23, 2026

Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol
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Do ADHD-impulsivity and BMI have shared polygenic and neural correlates?

Edward D Barker1,2, Alex Ing3,4, Francesca Biondo3,4

  • 1Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. ted.barker@kcl.ac.uk.

Molecular Psychiatry
|June 23, 2019
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Summary

Attention-Deficit/Hyperactivity Disorder (ADHD) and obesity share genetic links, with impulsivity playing a role. A common neural pathway may explain the connection between ADHD, obesity, and impulsivity, influencing genetic liability and observable traits.

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Existing research links Attention-Deficit/Hyperactivity Disorder (ADHD) to overweight and obesity.
  • Impulsivity, a key feature of ADHD, is thought to contribute to this association.
  • The neural and polygenic underpinnings of this link remain underexplored.

Purpose of the Study:

  • To investigate the neural and polygenic correlates of the association between ADHD, impulsivity, and Body Mass Index (BMI).
  • To examine shared neural substrates linking ADHD and BMI phenotypes and their polygenic risk scores (PRS).

Main Methods:

  • Utilized data from the IMAGEN study.
  • Analyzed associations between impulsivity symptoms, BMI, and their respective PRS.
  • Employed sparse partial least squared analysis (sPLS) to identify shared neural substrates.
  • Conducted mediation analysis to explore the role of neuroimaging findings.

Main Results:

  • Impulsivity symptoms and BMI were significantly associated, as were their PRS.
  • A shared neural substrate was identified linking both phenotypes and PRS.
  • Neuroimaging data mediated the association between ADHD PRS and impulsivity/BMI, and between BMI PRS and BMI/impulsivity.

Conclusions:

  • A common neural substrate may partially explain the shared genetic liability for ADHD and BMI.
  • This neural pathway may contribute to the observable phenotypic association between ADHD and obesity.