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Sarcomere Shortening of Pluripotent Stem Cell-Derived Cardiomyocytes using Fluorescent-Tagged Sarcomere Proteins.
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Pluripotent Stem Cell-Derived Cardiomyocyte Transplantation for Heart Disease Treatment

Shin Kadota1, Yuji Shiba2

  • 1Department of Regenerative Science and Medicine, Institute for Biomedical Sciences, Shinshu University, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.

Current Cardiology Reports
|June 23, 2019
PubMed

Insights

Pluripotent stem cell-derived cardiomyocytes (PSC-CMs) show promise for treating heart disease by regenerating heart tissue after transplantation. While generally safe, further research is needed to overcome challenges for widespread clinical use.

Area of Science:

  • Regenerative Medicine
  • Cardiology
  • Stem Cell Biology

Background:

  • Cardiovascular disease is a leading global cause of mortality.
  • Pluripotent stem cell-derived cardiomyocytes (PSC-CMs) offer potential for heart disease treatment through engraftment and remuscularization.
  • This review focuses on the clinical transplantation of PSC-CMs.

Purpose of the Study:

  • To provide an overview of PSC-CMs for clinical transplantation.
  • To discuss the functional benefits and challenges of PSC-CM transplantation in treating heart disease.

Main Methods:

  • Review of existing studies on PSC-CM transplantation.
  • Analysis of PSC-CM survival, engraftment, and functional integration in host hearts.
  • Evaluation of arrhythmias and immunosuppression requirements in preclinical models.

Main Results:

  • PSC-CMs survive, engraft, and form functional connections after transplantation.
  • Engrafted PSC-CMs mature over time in host hearts.
  • Transient arrhythmias were observed in large animal models; immunosuppression is necessary for allogeneic transplantation.

Conclusions:

  • PSC-CM transplantation shows potential for treating ischemic heart diseases.
  • Functional benefits are observed, but technological and biological limitations require further investigation.
  • Overcoming challenges is crucial for advancing PSC-CM therapy.
Abstract

Keywords:
CardiomyocyteCell therapyHeart diseasePluripotent stem cellTransplantation

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