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Intussusceptive Lymphangiogenesis in Lymphatic Malformations/Lymphangiomas
Lucio Díaz-Flores1, Ricardo Gutiérrez1, Maria D P García2
1Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, Tenerife, Spain.
Anatomical Record (Hoboken, N.J. : 2007)
|June 23, 2019
Summary
Intussusceptive lymphangiogenesis, a process where lymphatic vessels form new channels, was observed in lymphangiomas. This mechanism, similar to blood vessel intussusception, involves the formation of papillae, pillars, and septa, suggesting a piecemeal growth pattern.
Area of Science:
- Vascular Biology
- Pathology
- Histology
Background:
- Intussusception is a known mechanism in blood vessel angiogenesis but less studied in lymphatic vessels.
- Lymphangiomas, characterized by papillae, may exhibit similar intussusceptive processes.
- Understanding intussusceptive angiogenesis in lymphatics has clinical implications.
Purpose of the Study:
- To investigate the presence and characteristics of intussusceptive angiogenesis in lymphangiomas.
- To determine if papillae, pillars, folds, vessel loops, and septa are key structures in this process.
- To elucidate the formation mechanisms of these structures in lymphatic malformations.
Main Methods:
- Histological examination of 18 lymphangioma cases with intraluminal papillae.
- Serial sectioning and immunohistochemistry on selected cases with abundant papillae.
- Analysis of lymphatic-lymphatic vascular loops, interstitial tissue structures (ITSs), and pillars.
Main Results:
- Dilated lymphatic spaces formed vascular loops that dissected and encircled perilymphatic structures.
- Interstitial tissue structures and pillars, lined by anti-podoplanin-positive endothelial cells, protruded into lymphatic spaces.
- Observed splitting, remodeling, and fusion of papillae/pillars/folds, creating papillary networks and septa.
Conclusions:
- Intussusceptive lymphangiogenesis, characterized by vessel loops, papillae/pillars/folds, and septa, occurs in lymphangiomas.
- This process suggests a piecemeal intussusception mechanism in lymphatic vessel development.
- Findings provide a basis for further research into lymphatic intussusception and its clinical relevance.
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