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Proposal for an ecofriendly and economic strategy for efficient radioiodination of coumarin derivatives
Nejla Khatir-Hamdi1, Malika Makhloufi-Chebli2, Artur M S Silva3
1Centre de Recherche Nucléaire de Draria (CRND), BP 43, Sebala, Draria, Algeria; Département du Génie de l'Environnement, École Nationale Polytechnique, 10 Avenue des Frères Ouadek, Hassen badi, BP 182, 16200, El Harrach, Algiers, Algeria.
Abstract:
Combination of the calculation of reactivity descriptors and the cold iodine test for some coumarin derivatives was used in order to optimize the radioiodination reaction. The strongly nucleophilic predicted coumarins were subjected to the action of cold iodine. With two coumarins substituted at 3 by the 2-hydroxybenzoyl group, iodination did not occur but a product of intramolecular heterocyclization was obtained. This strategy is useful for economic and environmentally friendly radioiodination.
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