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Updated: Jan 23, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
What can copeptin tell us in patients with autosomal dominant polycystic disease?
Lise Bankir1, Daniel G Bichet2
1INSERM, Unité 1138, Centre de Recherche des Cordeliers, Paris, France; Sorbonne Université, Centre de Recherche des Cordeliers, Paris, France.
Abstract:
Vasopressin is known to contribute to disease progression in autosomal dominant polycystic disease (ADPKD) by its influence on cyclic adenosine monophosphate that directly promotes cyst growth. In addition, vasopressin probably contributes to progression by inducing glomerular hyperfiltration as shown in other forms of chronic kidney diseases. The measurement of plasma copeptin, a marker of vasopressin secretion, could help identify patients at higher risk of fast progression and those expected to benefit the most from vasopressin V2 receptor blockade. Further studies should evaluate the optimal level of suppression of vasopressin effects in autosomal dominant polycystic disease.
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