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Overview of Cutaneous T-Cell Lymphomas
Cecilia A Larocca1, Nicole R LeBoeuf1
1Department of Dermatology, Center for Cutaneous Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.
Hematology/Oncology Clinics of North America
|June 24, 2019
Summary
Non-Hodgkin's lymphoma (NHL) includes various lymphomas. Cutaneous T-cell lymphomas (CTCLs), a subset of NHLs, require integrated diagnosis and have limited curative options, with stem cell transplant offering the only potential cure.
Area of Science:
- Oncology
- Dermatology
- Hematology
Background:
- Non-Hodgkin's lymphoma (NHL) is a diverse group of systemic and cutaneous malignancies.
- Cutaneous T-cell lymphomas (CTCLs) constitute approximately 13% of all NHLs.
- CTCLs present heterogeneously with varied clinical and histologic features.
Purpose of the Study:
- To provide an overview of Cutaneous T-cell lymphomas (CTCLs) within the spectrum of Non-Hodgkin's lymphoma (NHL).
- To highlight the diagnostic complexities and therapeutic challenges associated with CTCLs.
- To emphasize the current treatment landscape and curative potential for advanced CTCLs.
Main Methods:
- Literature review of Non-Hodgkin's lymphoma and Cutaneous T-cell lymphomas.
- Synthesis of clinical, pathologic, and molecular diagnostic criteria for CTCLs.
- Analysis of current treatment strategies and outcomes for prevalent CTCL subtypes.
Main Results:
- Cutaneous T-cell lymphomas (CTCLs) are a significant subgroup of Non-Hodgkin's lymphoma (NHL).
- Mycosis fungoides and Sézary syndrome are the most common forms of CTCL.
- Diagnosis necessitates a multidisciplinary approach integrating clinical, pathological, and molecular data.
Conclusions:
- Effective management of CTCLs focuses on reducing morbidity and controlling disease progression.
- Hematopoietic stem cell transplantation represents the sole potentially curative therapeutic option for CTCLs.
- Further research is warranted to improve therapeutic outcomes for these lymphomas.
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