Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

3.1K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
3.1K
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

19.3K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.3K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

8.9K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
8.9K
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

1.4K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.4K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.1K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.1K
Disorders of Leukocytes01:27

Disorders of Leukocytes

1.8K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Growth factor independent 1B is a metabolic regulator that exerts pleiotropic effects on platelet function.

Journal of thrombosis and haemostasis : JTH·2025
Same author

Unraveling facets of MECOM-associated syndrome: somatic genetic rescue, clonal hematopoiesis, and phenotype expansion.

Blood advances·2024
Same author

Impact of perioperative direct oral anticoagulant assays: a multicenter cohort study.

Hospital practice (1995)·2023
Same author

Treatment of immune thrombocytopenia in Australian adults: A multicenter retrospective observational study.

Research and practice in thrombosis and haemostasis·2022
Same author

White pupae phenotype of tephritids is caused by parallel mutations of a MFS transporter.

Nature communications·2021
Same author

Ionotropic glutamate receptors in platelets: opposing effects and a unifying hypothesis.

Platelets·2020

Related Experiment Video

Updated: Jan 23, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.6K

Acquired platelet function disorders.

Yvonne Brennan1, Marie Levade2, Christopher M Ward3

  • 1Department of Haematology, Westmead Hospital, Westmead, NSW, Australia.

Thrombosis Research
|June 24, 2019
PubMed
Summary
This summary is machine-generated.

Acquired platelet dysfunction can cause bleeding. Light transmission aggregometry (LTA) is key for diagnosis, with management focusing on causes and treatments like antifibrinolytics or platelet transfusions.

More Related Videos

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.2K
Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

770

Related Experiment Videos

Last Updated: Jan 23, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.6K
Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.2K
Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

770

Area of Science:

  • Hematology
  • Clinical Medicine
  • Pharmacology

Background:

  • Acquired platelet function disorders present with mucocutaneous bleeding.
  • Diagnosis often relies on light transmission aggregometry (LTA), despite newer assays.
  • Causes include medications, diet, medical conditions, and procedures.

Purpose of the Study:

  • To review the causes of acquired platelet dysfunction.
  • To discuss diagnostic approaches, emphasizing LTA.
  • To summarize management strategies for acquired platelet function defects.

Main Methods:

  • Literature review of acquired platelet dysfunction.
  • Discussion of diagnostic modalities, including LTA.
  • Summary of current management strategies.

Main Results:

  • Common causes of acquired platelet dysfunction identified.
  • Importance of considering newer drugs like ibrutinib highlighted.
  • Limited clinical trial data for management strategies noted.

Conclusions:

  • Acquired platelet dysfunction requires consideration in bleeding patients.
  • LTA remains the gold standard for diagnosis.
  • Management involves addressing the cause and utilizing agents like antifibrinolytics, desmopressin, or platelet transfusions.