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Transmission events and antimicrobial susceptibilities of methicillin-resistant Staphylococcus argenteus in Stockholm

C G Giske1, F Dyrkell2, D Arnellos2

  • 1Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|June 24, 2019
PubMed
Abstract

Insights

Methicillin-resistant Staphylococcus argenteus showed clonal spread in Stockholm, with a family transmission event identified. Surveillance is crucial for this emerging pathogen, which can be detected by MALDI-TOF MS.

Area of Science:

  • Microbiology
  • Genetics
  • Epidemiology

Background:

  • Staphylococcus argenteus, a novel species since 2015, is increasingly reported.
  • Methicillin-resistant S. argenteus (MRSA) requires ongoing investigation.
  • Understanding MRSA epidemiology and resistance is critical.

Purpose of the Study:

  • To investigate genetic links and antimicrobial resistance of MRSA in Stockholm.
  • To analyze the spread and characteristics of S. argenteus isolates.
  • To assess the utility of MALDI-TOF MS for S. argenteus identification.

Main Methods:

  • Whole-genome sequencing and MALDI-TOF MS were used to identify 16 MRSA isolates.
  • Genomic analyses included SNP phylogeny, k-mer analysis, and cgMLST.
  • Antimicrobial susceptibility testing was performed using broth microdilution.

Main Results:

  • Isolates belonged to sequence types ST1223, ST2250, and ST2793.
  • SNP and cgMLST analyses indicated clonal spread of MRSA starting in 2007.
  • Four isolates exhibited resistance to non-β-lactam antimicrobials.

Conclusions:

  • A MRSA transmission event within a family was identified.
  • Non-β-lactam resistance in S. argenteus necessitates continued surveillance.
  • MALDI-TOF MS with updated databases enables clinical detection of S. argenteus.
Keywords:
Antimicrobial susceptibilityMolecular epidemiologyStaphylococcus argenteusTransmission eventsWhole-genome sequencing

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