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Published on: September 2, 2010
Phenolic constituents with neuroprotective activities from Hypericum wightianum
Ling Yang1, Zi-Ming Wang2, Yun Wang2
1School of Pharmacy and Yunnan Key Laboratory of Natural Medicine Pharmacology, Kunming Medical University, Kunming, 650500, PR China; Tongren Polytechnic College, Guizhou, 554300, PR China.
Abstract:
Five undescribed phenolic compounds, inclusing a depsidone derivative, hyperwightin A, a flavone derivative, hyperwightin B, and three benzophenone glycosides, hyperwightins C-E, along with four known ones were isolated from the 95% EtOH extract of the whole plants of Hypericum wightianum. Structures of the obtained compounds were elucidated by spectroscopic analyses. The protective effects of the isolates against corticosterone-induced PC12 cell injury were assessed. Hyperwightin E, petiolin G and hyperxanthone exhibited noticeable neuroprotection at 10 μM.
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