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Updated: Jan 23, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Hormone replacement therapy: informed consent without assessment?
Toni C Saad1, Bruce Philip Blackshaw2, Daniel Rodger3
1Cardiology, University Hospital of Wales Healthcare NHS Trust, Cardiff, UK.
Requiring mental health assessment before hormone replacement therapy (HRT) for gender dysphoria is ethically sound. This process aligns with informed consent models and addresses higher rates of psychiatric conditions in transgender individuals.
Area of Science:
- Medical Ethics
- Transgender Healthcare
- Psychiatry
Background:
- Florence Ashley argues against mandatory mental health assessment for gender dysphoria patients seeking hormone replacement therapy (HRT), deeming it unethical.
- Ashley suggests this requirement may reflect unconscious bias against transgender individuals.
Purpose of the Study:
- To refute Florence Ashley's claims regarding the ethics of pre-HRT mental health assessments for gender dysphoria.
- To clarify the distinction between symptom self-reporting and self-diagnosis within the informed consent model.
- To support the necessity of psychological assessment and referral for transgender patients undergoing HRT.
Main Methods:
- Critically analyzing Florence Ashley's arguments on informed consent and HRT.
- Comparing the informed consent model for HRT with that of cosmetic surgery.
- Reviewing literature on psychiatric morbidity prevalence in the transgender population.
Main Results:
- Ashley conflates symptom self-reporting with self-diagnosis, deviating from standard informed consent principles.
- The informed consent model for cosmetic surgery, which Ashley favors, also includes psychological assessment and referral.
- Elevated psychiatric morbidity rates in transgender individuals support the need for mental health evaluation before HRT.
Conclusions:
- The requirement for mental health assessment before HRT for gender dysphoria is ethically justified and aligns with established medical practices.
- This process ensures informed consent and addresses the specific health needs of transgender patients.
- The findings support the continued use of psychological evaluation as a standard of care in gender-affirming hormone therapy.
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