Related Experiment Video

Updated: Jan 23, 2026

Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor
09:21

Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor

Published on: January 4, 2016

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Bile Acid-Activated Receptors: A Review on FXR and Other Nuclear Receptors

Dong-Ju Shin1, Li Wang2,3

  • 1Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA. dong-ju.shin@uconn.edu.

Handbook of Experimental Pharmacology
|June 24, 2019
PubMed

Insights

Nuclear receptors (NRs) regulate bile acid homeostasis and metabolism. These signaling pathways are integral to lipid, glucose, and energy balance.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Metabolic Research

Background:

  • Nuclear receptors (NRs) are crucial ligand-dependent transcription factors governing biological processes.
  • Bile acids, synthesized in the liver, act as signaling molecules regulating metabolism, detoxification, and regeneration.
  • NRs and bile acids form an intricate signaling network impacting various physiological functions.

Purpose of the Study:

  • To review the role of nuclear receptors in maintaining bile acid homeostasis.
  • To highlight the regulatory functions of NRs in bile acid, lipid, and glucose metabolism.
  • To elucidate the interplay between bile acid signaling and nuclear receptor activity.

Main Methods:

  • Literature review focusing on nuclear receptors and bile acid signaling.
  • Analysis of the regulatory roles of specific NRs (FXR, PXR, CAR, VDR, SHP) in bile acid metabolism.
  • Examination of NR involvement in lipid and glucose metabolic pathways.

Main Results:

  • Nuclear receptors are integral to bile acid signaling and homeostasis.
  • Specific NRs like FXR, PXR, CAR, and VDR play key roles in regulating bile acid metabolism.
  • NRs significantly influence lipid and glucose metabolism through bile acid signaling pathways.

Conclusions:

  • Nuclear receptors are essential regulators of bile acid homeostasis.
  • The interplay between bile acids and NRs is critical for metabolic regulation.
  • Understanding these pathways offers insights into metabolic disorders and therapeutic strategies.
Keywords:
Bile acidsMetabolismNuclear receptor

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