Related Experiment Video
Updated: Jan 23, 2026
06:51
A Preclinical Murine Model of Hepatic Metastases
Published on: September 27, 2014
30.3K
Single-isocenter volumetric-modulated Dynamic WaveArc therapy for two brain metastases
Megumi Uto1, Kengo Ogura1,2, Nobutaka Mukumoto1
1Department of Radiation Oncology and Image-Applied Therapy, Kyoto University Graduate School of Medicine, 54, Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Japanese Journal of Radiology
|June 24, 2019
Summary
Volumetric-modulated Dynamic WaveArc therapy (VMDWAT) offers improved dose distribution and reduced treatment time for two brain metastases compared to volumetric-modulated arc therapy (VMAT). This advanced VMDWAT technique shows promise for brain metastasis treatment.
Area of Science:
- Radiation Oncology
- Medical Physics
- Neurosurgery
Background:
- Brain metastases present a significant clinical challenge requiring precise radiation delivery.
- Volumetric-modulated arc therapy (VMAT) is a standard technique, but optimizing dose distribution and treatment time remains crucial.
- Newer techniques like VMDWAT aim to enhance treatment efficacy and patient comfort.
Purpose of the Study:
- To compare the dose distribution and treatment time of single-isocenter VMDWAT with VMAT for patients with two brain metastases.
- To evaluate the efficacy of VMDWAT using advanced planning techniques on the Vero4DRT system.
Main Methods:
- A planning study involving 20 patients with two brain metastases (planning target volume > 2.0 cm³).
- Both VMAT and VMDWAT plans were created with a single isocenter, delivering 28 Gy in five fractions.
- Target conformity was assessed using modified RTOG-CI (mRTOG-CI) and IP-CI (mIP-CI) indices.
Main Results:
- VMDWAT demonstrated significantly improved target conformity (mRTOG-CI and mIP-CI) compared to VMAT.
- VMDWAT reduced the volume of normal brain tissue receiving high doses (25 and 28 Gy).
- Mean treatment time was significantly shorter with VMDWAT than with VMAT.
Conclusions:
- Single-isocenter VMDWAT offers superior dose distribution and reduced treatment time for two brain metastases compared to VMAT.
- VMDWAT represents a promising advancement for the treatment of multiple brain metastases, enhancing therapeutic outcomes.
More Related Videos
Related Concept Videos
00:59Gene Therapy
27.4K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.4K
02:20Dynamic Equilibrium
62.0K
A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
62.0K
01:26Group Therapy
379
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
379
01:29Psychodynamic Therapy
533
Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...
533
01:24Humanistic Therapy
340
Humanistic therapies emphasize personal growth, self-understanding, and the fulfillment of human potential. Rooted in the belief that individuals inherently strive toward self-actualization, these approaches encourage clients to explore their feelings and experiences in a supportive, nonjudgmental environment. Humanistic therapies differ from psychodynamic approaches by focusing on conscious experiences, present circumstances, and the potential for self-improvement rather than past conflicts...
340
01:26Modeling in Therapy
395
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
395