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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Updated: Jan 23, 2026

Infrared Thermography for the Detection of Changes in Brown Adipose Tissue Activity
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ComBATing aging-does increased brown adipose tissue activity confer longevity?

Justin Darcy1, Yu-Hua Tseng2,3

  • 1Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA, 02215, USA.

Geroscience
|June 24, 2019
PubMed
Summary
This summary is machine-generated.

Brown adipose tissue (BAT) generates heat to maintain body temperature and acts as a metabolic sink. Targeting BAT may offer therapeutic potential for obesity and extend lifespan and healthspan.

Keywords:
AgingBrown adipose tissueMetabolismThermogenesis

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Area of Science:

  • Metabolic research
  • Thermogenesis
  • Adipose tissue biology

Background:

  • Brown adipose tissue (BAT) is crucial for thermogenesis via uncoupling protein 1 (UCP1).
  • BAT functions as a metabolic sink, consuming glucose and lipids.
  • The presence of BAT in adult humans has spurred research into its therapeutic potential.

Purpose of the Study:

  • To review the thermogenic program of BAT.
  • To explore BAT's function as a secretory organ.
  • To compare BAT in mice and humans, and examine its role in aging.

Main Methods:

  • Literature review of BAT research.
  • Analysis of BAT's thermogenic mechanisms.
  • Comparison of BAT across species and age.

Main Results:

  • BAT's UCP1 facilitates heat production by uncoupling oxidative phosphorylation.
  • BAT's metabolic activity impacts glucose and lipid uptake.
  • BAT's functions show overlap with biomarkers for extended lifespan and healthspan.

Conclusions:

  • BAT is a key player in thermoregulation and metabolic health.
  • Understanding BAT differences in mice and humans is critical for therapeutic development.
  • Targeting BAT presents a promising strategy for promoting longevity and healthspan.