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Updated: Jan 23, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
A new demethyl abietane diterpenoid from the roots of Tripterygium wilfordii
Peng Li1,2, Shao-Xin Shen2, Ling-Xue Liu2
1Department of Natural Medicine, School of Pharmacy, Fujian Medical University, Fuzhou, P. R. China.
Abstract:
A new demethyl abietane diterpenoid, Triptotin K (3) together with three known compounds, friedelin (1), canophyllal (2), and triptonoterpene (4) were isolated from the roots of Tripterygium wilfordii Hook. f. by silica gel column and preparative high performance liquid chromatography. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Triptotin K showed cytotoxic activities against KB, KBv200, HepG2, and MCF-7/ADM cells lines with IC50 values of 29.88, 36.50, 39.55, and 41.38 μM, respectively.
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