Related Experiment Video

Updated: Jan 23, 2026

Intraluminal Middle Cerebral Artery Occlusion MCAO Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Mice
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Intraluminal Middle Cerebral Artery Occlusion MCAO Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Mice

Published on: May 8, 2011

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Occurrence of priapism after transient right MCAO in Swiss albino mice

Kobra Akhoundzadeh1,2, Abedin Vakili2

  • 1a Faculty of Nursing and Midwifery , Qom University of Medical Sciences , Qom , Iran.

Somatosensory & Motor Research
|June 25, 2019
PubMed

Insights

Priapism, a persistent erection, occurs in 65% of male mice after middle cerebral artery occlusion (MCAO) stroke. This condition may indicate stroke severity and warrants further investigation in animal models.

Area of Science:

  • Neuroscience
  • Animal Models of Disease
  • Urology

Background:

  • Sexual dysfunction is underreported in animal models post-stroke.
  • Priapism incidence and its correlation with neurological deficits after stroke remain largely unexplored in preclinical research.

Purpose of the Study:

  • To investigate the occurrence of priapism in Swiss albino mice following right middle cerebral artery occlusion (MCAO).
  • To compare neurological scores and apoptosis rates between mice that developed priapism and those that did not after stroke.

Main Methods:

  • Swiss albino mice underwent 45 minutes of right MCAO followed by 7 days of reperfusion.
  • Daily observation for priapism, neurological assessment, and TUNEL assay for apoptosis were performed post-MCAO.

Main Results:

  • Priapism was observed in 65% of mice after MCAO, typically appearing by day 2.
  • Mice experiencing priapism exhibited more severe neurological deficits compared to unaffected stroke mice.
  • Apoptosis levels were compared between the priapism-affected and unaffected groups (specific results not detailed in abstract).

Conclusions:

  • Priapism is a frequent occurrence in Swiss albino mice after right MCAO.
  • Priapism following stroke may serve as a potential indicator of stroke severity in this animal model.
  • Further research is recommended to determine priapism incidence across different animal species used in stroke studies.
Keywords:
Priapismapoptosiscerebral ischaemiahypersexualityneurological assessment

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