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Updated: Jan 23, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
20.8K
Autoantibodies in interstitial lung diseases
Brittany R Stevenson1, Grace A Thompson1, Monalyssa C Watson2
1Department of Immunology, PathWest Laboratory Medicine, Perth, WA, Australia; Department of Clinical Immunology, Sir Charles Gairdner Hospital, Perth, WA, Australia.
Pathology
|June 25, 2019
Summary
Expanded autoantibody testing in interstitial lung disease (ILD) patients reveals high rates of autoimmune markers, even when initial tests are negative. This comprehensive approach aids early diagnosis of connective tissue disease-associated ILD.
Area of Science:
- Rheumatology
- Pulmonology
- Immunology
Background:
- Current guidelines suggest limited autoantibody testing for interstitial lung disease (ILD) diagnosis.
- This approach may miss autoimmune conditions when ILD is the primary manifestation.
Purpose of the Study:
- To evaluate the utility of extended autoantibody profiling in a well-characterized ILD cohort.
- To identify patients with clinically significant autoantibodies missed by standard testing protocols.
Main Methods:
- Retrospective analysis of stored serum from 80 ILD patients.
- Comprehensive autoimmune serology including anti-nuclear antibodies, extractable nuclear antigen antibodies, rheumatoid factor, and myositis antibodies.
Main Results:
- 70% of ILD patients (56/80) had positive autoimmune serology.
- Anti-nuclear antibodies were most common (42.5%), followed by myositis antibodies (16.2%).
- 13.7% of patients negative for anti-nuclear antibodies had other significant disease-associated autoantibodies.
Conclusions:
- Extended autoantibody testing can detect connective tissue disease-associated ILD irrespective of subtype.
- This comprehensive panel aids in diagnosing systemic autoimmunity prior to extra-pulmonary symptoms.
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