Related Experiment Video
Updated: Jan 23, 2026

Development of an In Vitro Ocular Platform to Test Contact Lenses
Published on: April 6, 2016
Effects of a semi-scleral contact lens on refraction and higher order aberrations
Mukesh Kumar1, Rohit Shetty1, Debarun Dutta2
1Cornea and Refractive Department, Narayana Nethralaya, Bangalore, India.
Purpose:
To investigate effects of Rose K2 XL semi-scleral contact lenses (Menicon Co.) on visual acuity and higher-order aberrations in eyes with irregular corneas.
Methods:
One hundred and twelve eyes of 84 patients fitted with Rose K2 XL lenses were analysed. Participants were in 4 clinical groups: keratoconus, intra-corneal ring segments, radial keratotomy, and penetrating keratoplasty. Corrected distance visual acuity and ocular aberrations were determined before lens wear and 60 min into lens wear. The i-Trace aberrometer was used to determine aberrations at 4.5 mm pupil size.
Results:
There were 55, 22, 19 and 16 eyes in keratoconus, intra-corneal ring segments, radial keratotomy and penetrating keratoplasty groups, respectively. Before lens wear, eyes had poor corrected distance vision acuity (mean and standard deviation +0.55 ± 0.33 logMAR), high negative spherical equivalent refraction (-6.4 ± 3.7 D), high cylindrical errors (4.5 ± 2.2 D), large higher-order root-mean-squared (HO-RMS) aberration (1.5 ± 1.3 μm) and large higher-order aberration components. Cylinder was particular high for the penetrating keratoplasty group (mean 5.9 ± 2.5 D), root-mean-squared third-order coma was lowest for the radial keratotomy group (0.7 ± 1.0 μm), and fourth-order spherical aberration was highly negative for the intra-corneal ring segment group (co-efficient -0.4 ± 0.7 μm). With lens wear, the values changed considerably. Corrected distance visual acuity improved by 0.51 ± 0.31 logMAR, cylinder decreased by 3.6 ± 2.1 D, HO-RMS aberration reduced by 1.1 ± 1.2 μm, and higher-order aberration components decreased considerably. Magnitudes of group changes reflected the magnitudes before lens wear.
Conclusions:
Rose K2 XL semi-scleral contact lenses were effective in improving vision and reducing ocular aberrations for eyes with irregular corneas.
Related Concept Videos
Contact-dependent Signaling
Gap Junctions
In animal cells, gap junctions are formed...
Contact Angle
The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive...
Influence of Earth's Curvature and Atmospheric Refraction on Leveling
Biological Effects of Radiation
Buffer Effectiveness
The buffer capacity is the amount of acid or base that can be added to a given volume...
Framing Effects

