Related Experiment Video
Updated: Jan 23, 2026
Coculture Assays to Study Macrophage and Microglia Stimulation of Glioblastoma Invasion
Published on: October 20, 2016
Harnessing Microglia and Macrophages for the Treatment of Glioblastoma
Ioanna Prionisti1,2, Léo H Bühler1, Paul R Walker3
1Division of Digestive and Transplantation Surgery, Geneva University Hospitals, Geneva, Switzerland.
Abstract:
Glioblastoma multiforme (GBM) is the most malignant form of brain tumors, with a dismal prognosis. During the course of the disease, microglia and macrophages both infiltrate the tumor microenvironment and contribute considerably in glioma development. Thus, tumor-associated microglia and macrophages have recently emerged as potentially key therapeutic targets. Here, we review the physiology of microglia and their responses in brain cancer. We further discuss current treatment options for GBM using radiotherapy, and novel advances in our knowledge of microglia physiology, with emphasis on the recently discovered pathway that controls the baseline motility of microglia processes. We argue that the latter pathway is an interesting therapeutic avenue to pursue for the treatment of glioblastoma.
Insights
Glioblastoma multiforme (GBM), a severe brain cancer, involves microglia and macrophages in tumor growth. Targeting microglia motility pathways presents a promising new therapeutic strategy for GBM treatment.
Area of Science:
- Neuro-oncology
- Immunology
- Cellular Physiology
Background:
- Glioblastoma multiforme (GBM) is an aggressive brain tumor with poor outcomes.
- Tumor-associated microglia and macrophages are key players in glioma development within the tumor microenvironment.
- These cells are emerging as critical therapeutic targets for brain cancer.
Purpose of the Study:
- To review microglia physiology and their role in brain cancer.
- To discuss current glioblastoma treatments, including radiotherapy.
- To highlight novel insights into microglia physiology and potential therapeutic pathways.
Main Methods:
- Literature review of microglia physiology in brain cancer.
- Analysis of current glioblastoma treatment modalities.
- Focus on a recently identified pathway regulating microglia process motility.
Main Results:
- Microglia and macrophages significantly influence glioma development.
- Understanding microglia physiology offers new therapeutic avenues.
- A specific pathway controlling microglia motility is identified as a potential target.
Conclusions:
- Targeting tumor-associated microglia and macrophages is a promising strategy for GBM.
- The pathway controlling microglia process motility represents a novel therapeutic target for glioblastoma.
- Further research into microglia-targeting therapies could improve GBM prognosis.
Related Concept Videos
01:24Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
01:22Alzheimer's Disease: Treatment
01:27Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
02:56Treatment Resistant Cancers
01:20Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
01:24Treatment Strategies for Psychological Disorders
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...