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Updated: Jan 23, 2026

Experimental Methods to Study Human Postural Control
Published on: September 11, 2019
Stain control with two experimental dentin hypersensitivity toothpastes containing spherical silica: a randomised,
Stephen Mason1, Sarah Young1, Mako Araga2
1GSK Consumer Healthcare, St George's Avenue, Weybridge, Surrey KT13 0DE UK.
New spherical silica toothpastes show promising extrinsic dental stain removal. Even at low concentrations, these novel formulations offer effective cleaning comparable to standard abrasives.
Area of Science:
- Dental hygiene research
- Materials science in oral care
- Abrasive technology
Background:
- Extrinsic dental stains impact aesthetics and oral health.
- Traditional toothpastes rely on standard abrasive silica for stain removal.
- Novel abrasive materials are being explored for enhanced cleaning efficacy.
Purpose of the Study:
- To compare the extrinsic dental stain removal efficacy of toothpastes with novel spherical silica against those with standard silica.
- To evaluate the safety and tolerability of experimental toothpaste formulations.
- To rank the performance of different silica concentrations and types in stain removal.
Main Methods:
- A randomized controlled trial involving 123 adults with extrinsic dental stain.
- Participants brushed twice daily for 8 weeks with one of four experimental or marketed toothpastes.
- Stain removal was assessed using the MacPherson modification of the Lobene stain index.
Main Results:
- A clear ranking order for extrinsic dental stain removal was established.
- The experimental 1% spherical silica toothpaste demonstrated the highest efficacy.
- All tested toothpaste formulations were generally well tolerated by participants.
Conclusions:
- Toothpastes containing low concentrations of novel spherical silica exhibit significant extrinsic dental stain removal capabilities.
- These findings support the further development of spherical silica as an effective and safe dental abrasive.
- The study suggests a potential for improved cleaning performance with optimized abrasive formulations.
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