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Suffering from Cerebral Small Vessel Disease with and without Metabolic Syndrome

Tatjana Bošković Matić1, Gordana Toncev2, Aleksandar Gavrilović2

  • 1Clinical Center Kragujevac, Clinic of neurology, Zmaj Jovina 30, 34000 Kragujevac, Serbia.

Open Medicine (Warsaw, Poland)
|June 25, 2019
PubMed

Insights

Metabolic syndrome worsens cognitive impairment and depression in patients with cerebral small vessel disease (CSVD). This finding highlights the compounded risks for individuals with both conditions, emphasizing the need for integrated care.

Area of Science:

  • Neurology
  • Metabolic Disorders
  • Cognitive Neuroscience

Background:

  • Cerebral small vessel disease (CSVD) is linked to cognitive decline and depression.
  • Metabolic syndrome is also independently associated with cognitive impairment and mood disorders.
  • The combined impact of CSVD and metabolic syndrome on cognitive and depressive symptoms was previously unclear.

Purpose of the Study:

  • To investigate the association between metabolic syndrome and cognitive impairment and depression in patients diagnosed with CSVD.
  • To specifically examine patients with CSVD exhibiting lacunar lesions or white matter hyperintensities.

Main Methods:

  • Prospective cohort study involving 74 hospitalized patients.
  • Cognitive function and depression assessments were conducted.
  • Patients were categorized based on the presence and type of CSVD (lacunary infarctions, white matter hyperintensities) and metabolic syndrome.

Main Results:

  • Cerebral small vessel disease (CSVD) was associated with cognitive impairment and depression.
  • Patients with lacunary lesions showed greater cognitive deficits and depressive symptoms compared to those with white matter hyperintensities.
  • Patients with CSVD and metabolic syndrome exhibited more severe cognitive impairment and depression than those with CSVD alone.

Conclusions:

  • Metabolic syndrome exacerbates cognitive impairment in patients with CSVD.
  • Metabolic syndrome intensifies depressive symptoms in individuals with CSVD.
  • The findings underscore the detrimental effect of metabolic syndrome on neurological and psychological health in the context of CSVD.
Abstract

Keywords:
cerebral small vessel diseasecognitive impairmentdepressionmetabolic syndrome

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