Related Experiment Video
Updated: Jan 23, 2026

Solid Plate-based Dietary Restriction in Caenorhabditis elegans
Published on: May 28, 2011
Sex differences in the response to dietary restriction in rodents
Alice E Kane1,2, David A Sinclair1,3, James R Mitchell4
1Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Abstract:
Dietary restriction (DR) remains the most reproducible and consistent laboratory intervention to extend lifespan and improve health in mammals. DR has been primarily characterized in males due to issues of cost, perceived heightened variability amongst females, and the misconception that the reproductive system is the only important difference between sexes in mammals. In reality, existing data point to clear sex differences in mammalian responses to DR. Here we discuss recent advances in our understanding of sex differences in the responses to DR in rodent models.
Related Concept Videos
Dietary Connections
Sex-linked Disorders
Restriction Enzymes
The host bacteria protect their own genomic DNA from these enzymes by methylating these sites. Some...
Proteins: Dietary Sources and Requirements
Carbohydrates: Dietary Sources and Requirements
Lipids: Dietary Sources and Requirements

