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Updated: Jan 23, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
Published on: April 8, 2013
Model of Left Ventricular Contraction: Validation Criteria and Boundary Conditions
Aditya V S Ponnaluri1, Ilya A Verzhbinsky2, Jeff D Eldredge1
1Department of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Abstract:
Computational models of cardiac contraction can provide critical insight into cardiac function and dysfunction. A necessary step before employing these computational models is their validation. Here we propose a series of validation criteria based on left ventricular (LV) global (ejection fraction and twist) and local (strains in a cylindrical coordinate system, aggregate cardiomyocyte shortening, and low myocardial compressibility) MRI measures to characterize LV motion and deformation during contraction. These validation criteria are used to evaluate an LV finite element model built from subject-specific anatomy and aggregate cardiomyocyte orientations reconstructed from diffusion tensor MRI. We emphasize the key role of the simulation boundary conditions in approaching the physiologically correct motion and strains during contraction. We conclude by comparing the global and local validation criteria measures obtained using two different boundary conditions: the first constraining the LV base and the second taking into account the presence of the pericardium, which leads to greatly improved motion and deformation.
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