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Hemoglobin Concentration Reference Interval Revisited: a Nationwide Study from Korea.
Clinical Laboratory
|June 25, 2019
Summary
The current anemia cutoff may misdiagnose many elderly individuals. This study suggests adjusting hemoglobin levels for accurate anemia diagnosis in older populations.
Area of Science:
- Gerontology
- Hematology
- Public Health
Background:
- Anemia is a significant contributor to mortality in the elderly.
- The World Health Organization's hemoglobin reference interval for anemia has not been updated in 50 years.
Purpose of the Study:
- To determine the actual hemoglobin concentration in the Korean population.
- To evaluate the accuracy of current anemia diagnostic cutoffs in the elderly.
Main Methods:
- Analysis of 6,759,566 participants from the Korean National Health Insurance (NHI) health screening program (2009-2013).
- Statistical analysis of hemoglobin concentration data across different age groups.
Main Results:
- A substantial portion of the study population was classified as anemic based on current standards.
- Mean hemoglobin levels were 14.8 g/dL (men) and 12.8 g/dL (women).
- Hemoglobin concentration decreased with age, indicating a potential need for age-specific cutoffs.
Conclusions:
- The current lower cutoff for anemia may lead to overdiagnosis in certain populations.
- A large, representative dataset supports the need to adjust anemia diagnostic criteria, particularly for the elderly.
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