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Nationwide survey on cerebral amyloid angiopathy in Japan

K Sakai1, M Ueda2, W Fukushima3

  • 1Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

European Journal of Neurology
|June 25, 2019
PubMed

Insights

This study estimates the prevalence of cerebral amyloid angiopathy-related intracerebral hemorrhage (CAA-related ICH) and inflammation (CAA-ri) in Japan. It found approximately 5900 cases of CAA-related ICH and 170 cases of CAA-ri, detailing their clinical features.

Area of Science:

  • Neurology
  • Epidemiology
  • Clinical Research

Background:

  • Cerebral amyloid angiopathy (CAA) is a growing concern, leading to intracerebral hemorrhage (ICH) and inflammation/vasculitis (CAA-ri).
  • Understanding the epidemiology of these conditions in Japan is crucial for public health planning.

Purpose of the Study:

  • To estimate the total number of patients diagnosed with CAA-related ICH and CAA-ri in Japan.
  • To analyze the clinical features and demographic characteristics of these patient populations.

Main Methods:

  • A nationwide survey involving questionnaires sent to randomly selected hospitals across Japan.
  • Data collection spanned from January 2012 to December 2014, with response rates analyzed.

Main Results:

  • An estimated 5900 cases of CAA-related ICH and 170 cases of CAA-ri were identified in Japan.
  • CAA-related ICH predominantly affected women, with onset around 78.4 years, often in the frontal lobe.
  • CAA-ri presented with cognitive impairment and headache, median onset at 75 years, and frequent neurological signs.

Conclusions:

  • The study provides crucial epidemiological data on CAA-related ICH and CAA-ri in Japan.
  • Estimated prevalence rates were 4.64 per 100,000 for CAA-related ICH and 0.13 per 100,000 for CAA-ri.
Abstract

Keywords:
cerebral amyloid angiopathyhemorrhageinflammationnationwide surveyvasculitis

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