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Updated: Jan 23, 2026

Batch Immunostaining for Large-Scale Protein Detection in the Whole Monkey Brain
Published on: July 27, 2009
[Quantitative susceptibility mapping of ultra-high resolution monkey brain in vivo at 9.4 T]
Qingqing Wen1, Hongyi Yang2, Kai Zhong3
1High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, P.R.China;University of Chinese Academy of Sciences, Beijing 100049, P.R.China.
Abstract:
Quantitative susceptibility mapping (QSM) can provide tissue susceptibility information and has been adapted for clinical research and diagnosis. QSM of monkey brain in vivo at 9.4 T has not been demonstrated so far. In this study 9.4 T in vivo monkey brain QSM was performed with 200 μm isotropic high-resolution. It was found that the inherent singularity problem for QSM diverged significantly at ultra-high image resolution during regularization process and resulted in severe image artifacts. The K-space division (TKD) was applied to eliminate the artifacts, with an optimal threshold level between 0.2 and 0.3. High resolution QSM of monkey brain in vivo can thus provide a novel tool for brain research.
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