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Buprenorphine treatment for opioid use disorder: recent progress
Suprit Parida1,2, Kathleen M Carroll2, Ismene L Petrakis1,2
1a VA Connecticut Healthcare System, VA Connecticut Health System West Haven Campus , West Haven , CT , USA.
Expert Review of Clinical Pharmacology
|June 25, 2019
Summary
Newer long-acting buprenorphine (BUP) formulations for opioid use disorder (OUD) are non-inferior to traditional sublingual BUP. These advanced treatments show promise in reducing opioid use compared to placebo.
Area of Science:
- Pharmacology
- Public Health
- Addiction Medicine
Background:
- Opioid use disorder (OUD) presents a significant global public health challenge, particularly in the US.
- Buprenorphine (BUP) is a primary pharmacological treatment for OUD.
- Novel delivery systems for BUP are being developed to enhance treatment efficacy.
Purpose of the Study:
- To review available BUP products for OUD treatment.
- To focus on the efficacy and outcomes of newer long-acting BUP formulations.
- To identify research gaps and future directions in long-acting BUP development.
Main Methods:
- Literature search of PubMed, Google Scholar, and ClinicalTrials.gov.
- Inclusion of randomized clinical trials (RCTs) evaluating long-acting BUP products.
- Analysis of four RCTs: two on BUP implants and two on subcutaneous injectable BUP.
Main Results:
- Long-acting BUP formulations demonstrated non-inferiority to sublingual (SL) BUP in clinical trials.
- These newer formulations were more effective than placebo in reducing opioid use.
- Longer-acting formulations offer potential improvements in dosing flexibility.
Conclusions:
- While effective, the superiority of long-acting BUP over existing SL formulations requires further investigation.
- Comparative studies between long-acting and SL BUP are needed.
- Future research should assess outcomes like quality of life, long-term remission, and cost-effectiveness.
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