Combination of three-dimensional arterial spin labeling and stretched-exponential model in grading of gliomas

To evaluate the diagnostic value of combining 3D arterial spin labeling (ASL) and stretched-exponential diffusion model in grading of gliomas.A total of 72 patients with histo-pathology proved gliomas (34 low-grade, 38 high-grade) were included in this study. 3D ASL and multi-b diffusion weighted imaging (DWI) images were retrospectively analyzed. The ASL and DWI parameters-tumor blood flow (TBF), distributed diffusion coefficient (DDC), and diffusion heterogeneity α were compared between high-grade and low-grade groups and P < .05 was regarded as statistically significant. TBF was also normalized to the corresponding values in contralateral mirror regions of interest (ROI) (M-TBF), normal grey matter (G-TBF), and white matter (W-TBF) and were compared between high and low-grade tumors.TBF values were significantly higher in high-grade gliomas (P < .001). In stretched-exponential model, the α value of low-grade gliomas showed significant higher than high-grade gliomas group (P < .001), but there was no difference of DDC (P > .05). When TBF values were normalized to contralateral mirror ROI, normal grey matter and white matter, G-TBF showed the highest sensitivity and specificity for differentiation high-grade and low-grade gliomas. The area under area under curve (AUC) of G-TBF and α for glioma grading were 0.926 and 0.892, respectively. The area under AUC of the G-TBF combination with α was 0.960 and corresponding sensitivity and specificity were 94.1% and 98.7%.The combination of 3D ASL and stretched-exponential model parameters can be used to differentiate high-grade and low-grade gliomas. Combination G-TBF and α value can obtain best diagnostic performance.