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Association between cholelithiasis and sialolithiasis: Two longitudinal follow-up studies
So Young Kim1, Hyung-Jong Kim2, Hyun Lim3
1Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam.
Medicine
|June 25, 2019
Summary
This study investigated gallstones (cholelithiasis) and salivary stones (sialolithiasis) in a Korean population. Researchers found no significant association between these two conditions.
Area of Science:
- Gastroenterology and Otolaryngology
- Epidemiology
- Health Services Research
Background:
- Gallstones (cholelithiasis) and salivary stones (sialolithiasis) are common conditions affecting different glandular systems.
- Understanding potential associations between these conditions can inform clinical practice and public health strategies.
Purpose of the Study:
- To evaluate the association between cholelithiasis and sialolithiasis.
- To investigate the risk of developing sialolithiasis in patients with cholelithiasis.
- To examine the risk of developing cholelithiasis in patients with sialolithiasis.
Main Methods:
- Utilized the Korean National Health Insurance Service-National Sample Cohort (2002–2013).
- Study I: Cholelithiasis patients (n=21,170) were matched with controls (n=84,680) to assess sialolithiasis occurrence.
- Study II: Sialolithiasis patients (n=761) were matched with controls (n=3,044) to assess cholelithiasis occurrence.
- Stratified Cox proportional hazard models were used to determine hazard ratios (HRs).
Main Results:
- The HR for sialolithiasis in the cholelithiasis group was 1.49 (95% CI = 0.88-2.52, P = .14).
- The HR for cholelithiasis in the sialolithiasis group was 1.18 (95% CI = 0.53-2.59, P = .69).
- Statistical analyses did not reveal a significant association between cholelithiasis and sialolithiasis.
Conclusions:
- This large-scale cohort study found no evidence of an association between gallstones and salivary stones.
- The findings suggest that cholelithiasis and sialolithiasis may develop independently.
- Further research could explore other potential risk factors or pathogenetic mechanisms for each condition.
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