Influence of Ocular Dimensional Change on 24-Hour Intraocular Pressure Measurement With Contact Lens Sensor

We measured changes in the corneal morphology and intraocular pressure (IOP) before and after the use of contact lens sensor (CLS). Then, we investigated whether the ocular dimensional change affected the measured IOP value with CLS.

In this prospective study, we examined 112 eyes of glaucoma patients. We measured the IOP fluctuation using a Sensimed Triggerfish CLS. We measured the corneal morphology before and after making measurements using a CLS in anterior segment optic coherent optical coherence tomography and measured the IOP with a Goldmann applanation tonometer. We investigated the correlation between these ocular dimensional changes and the last IOP value with CLS.

Measurement with the CLS significantly increased the IOP (P=0.0305), made the corneal thickness (CT) significantly thicker (P<0.001), and increased the steeper meridian (P=0.0026). The last value of IOP-patterns recorded with CLS was significantly correlated with the IOP immediately after the measurement with Goldmann applanation tonometer (P=0.0134), was not significantly correlated with central and peripheral CT. The difference of steeper and flatter curvature between before and after measurement significantly correlated with the last value of IOP-patterns recorded with CLS.

Measurement with a CLS affects the IOP, CT, and corneal steeper meridian. From the last value of IOP-related patterns recorded with CLS, CLS could perceive accurate IOP. The change of corneal curvature might affect CLS output values.