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Related Experiment Video

Updated: Jan 23, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
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Co-Processed Particles: An Approach to Transform Poor Tableting Properties.

Rahul Roopwani1, Ira S Buckner1

  • 1Discipline of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282.

Journal of Pharmaceutical Sciences
|June 25, 2019
PubMed
Summary

Co-processing gabapentin with hydroxypropyl methylcellulose (Methocel®) significantly improved tablet strength and reduced capping. This method enhances poorly compressible drugs without high excipient levels.

Keywords:
co-processingcompactibilityinteractive mixingpowder compressionstrain rate sensitivitytabletstensile strength

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Gabapentin exhibits poor tableting properties, including low tensile strength and high ejection force.
  • Poor compressibility necessitates strategies to improve mechanical integrity for effective drug delivery.

Purpose of the Study:

  • To investigate co-processing as a method to enhance the mechanical properties of gabapentin tablets.
  • To evaluate the impact of hydroxypropyl methylcellulose (Methocel®) on gabapentin's tableting characteristics.

Main Methods:

  • Gabapentin was blended with hydroxypropyl methylcellulose (Methocel®) using high shear mixing to create an interactive mixture.
  • Tablets were compressed from the interactive mixture (<1% Methocel®) and evaluated on a material testing system (Instron®).

Main Results:

  • Co-processed gabapentin showed improved tablet tensile strength and strain rate sensitivity due to enhanced particle bonding.
  • A low-shear mixture with 10% Methocel® exhibited lower tensile strength and strain rate sensitivity.
  • Methocel® coating reduced die-wall friction, decreasing tablet capping and improving lubricity.

Conclusions:

  • Co-processing with low levels of Methocel® effectively improves the mechanical properties of poorly compressible drugs like gabapentin.
  • This technique offers a viable alternative to high excipient use and can benefit formulations sensitive to overlubrication.