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Updated: Jan 23, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
Prism adaptation enhances decoupling between the default mode network and the attentional networks
Meytal Wilf1, Andrea Serino2, Stephanie Clarke3
1MySpace Lab, Department of Clinical Neuroscience, Lausanne University and University Hospital (CHUV), Lausanne, Switzerland.
Prism adaptation (PA) rapidly alters brain network interactions. This study shows PA enhances decoupling between the Default Mode Network and attention networks, explaining behavioral changes in healthy individuals.
Area of Science:
- Neuroscience
- Cognitive Science
- Neuroimaging
Background:
- Prism adaptation (PA) studies visuomotor plasticity and spatial neglect.
- PA involves wearing prisms to induce visual displacement, leading to sensory-motor recalibration and after-effects.
- Previous neuroimaging linked PA to changes in the inferior parietal lobule and interhemispheric attention balance.
Purpose of the Study:
- To investigate how prism adaptation (PA) affects global cortical network interplay using resting-state functional connectivity.
- To compare resting-state connectivity patterns before and after PA with rightward-shifting prisms versus neutral lenses.
Main Methods:
- Resting-state functional connectivity was assessed in 26 participants (14 prism, 12 control) before and after a PA task.
- Global connectivity analysis identified changes in network interactions following prism exposure.
Main Results:
- PA significantly decreased functional connectivity in two Default Mode Network (DMN) nodes and the left anterior insula.
- Connectivity decreased between DMN nodes and attentional network areas (inferior frontal gyrus, anterior insula, superior temporal sulcus).
- The anterior insula showed decreased connectivity with multiple DMN areas.
Conclusions:
- Brief prism adaptation enhances the decoupling between the Default Mode Network and attention networks.
- Altered interplay between these networks likely underlies the rapid behavioral changes observed after PA in healthy individuals.
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