Effect of an LHRH-agonist on testicular microcirculation in hypophysectomized rats

The effect of an LHRH-agonist on testicular vasomotion was studied in adult hypophysectomized rats. At 0.5 and 1 h after injection of 1 microgram LHRH-agonist, no effect on vasomotion was observed, but after 2 h the pulsatile blood flow pattern had changed to continuous flow in 50% of the rats. At 4 h after treatment with LHRH-agonist, vasomotion was not detected in the testis of any rat. In addition, at the latter time an increased number of polymorphonuclear leucocytes (PMNs) were observed in testicular microvessels, and some PMNs had migrated into the interstitial space. These findings are discussed in relation to the well-known stimulatory effect of LHRH-agonists on testicular interstitial fluid volume.