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Thialysine and selenalysine incorporation into CHO cell proteins and its effects on cell growth
C Blarzino1, R Coccia, V Busiello
1Centro di Biologia Molecolare del C.N.R., Roma.
The Italian Journal of Biochemistry
|July 1, 1987
Abstract:
CHO cells can incorporate into proteins both thialysine and selenalysine when both are present together in the culture medium. Thialysine and selenalysine inhibit cell growth and cell viability. The inhibitory effect of either analog is additive. The inhibition of cell viability is related to the extent of protein lysine substitution by thialysine or selenalysine; it is however irrelevant whether lysine is substituted by one or the other analog or by both.