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Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma
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Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma

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Outcomes and Quality of Life of Systemic Therapy in Advanced Hepatocellular Carcinoma

Kehua Zhou1, Christos Fountzilas2

  • 1Catholic Health System Internal Medicine Training Program, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA. kehuazho@buffalo.edu.

Cancers
|June 26, 2019
PubMed

Insights

New systemic treatments improve outcomes for advanced hepatocellular carcinoma (HCC), but managing unique toxicities alongside cirrhosis is crucial for maintaining patient quality of life and treatment efficacy.

Area of Science:

  • Hepatology and Oncology
  • Clinical Pharmacology

Background:

  • Hepatocellular carcinoma (HCC) is a prevalent cancer often diagnosed at advanced stages with limited curative options.
  • Recent advancements include targeted therapies like kinase inhibitors (sorafenib, lenvatinib) and immunotherapies (nivolumab, pembrolizumab) for advanced HCC.
  • Cirrhosis, a common comorbidity, complicates treatment delivery and can exacerbate drug toxicities, impacting patient quality of life.

Purpose of the Study:

  • To review the efficacy and quality-of-life outcomes associated with modern systemic therapies for advanced HCC.
  • To provide clinicians with a reference for managing treatment-related toxicities in the context of cirrhosis.
  • To guide optimal management strategies balancing survival benefits and quality of life for advanced HCC patients.

Main Methods:

  • Systematic review of recent clinical trials and observational studies on systemic agents for advanced HCC.
  • Analysis of reported patient outcomes, including overall survival, progression-free survival, and quality-of-life metrics.
  • Evaluation of toxicity profiles and management strategies for common side effects, considering the impact of cirrhosis.

Main Results:

  • Modern systemic treatments have demonstrated improved long-term outcomes for patients with advanced HCC.
  • Treatment-related toxicities are common and can significantly affect patient quality of life, necessitating careful management.
  • Cirrhosis presents a significant challenge, potentially influencing drug efficacy and toxicity, and requiring tailored therapeutic approaches.

Conclusions:

  • Optimal management of advanced HCC requires a multidisciplinary approach, integrating modern systemic therapies with vigilant toxicity monitoring and cirrhosis management.
  • Balancing the benefits of novel agents with the risks of side effects is essential for preserving quality of life in patients with advanced HCC and cirrhosis.
  • Further research is needed to refine treatment strategies and supportive care for this complex patient population.
Keywords:
drug toxicityhepatocellular carcinomaimmunotherapymultikinase inhibitorsquality of life

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