Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Vaccinations

Vaccinations

Neurons: The Cell Body and the Dendrites

Neurons: The Cell Body and the Dendrites

A typical nerve cell comprises three main components: the cell body, dendrites, and the axon. The cell body, also known as the soma or perikaryon, serves as the central biosynthetic hub housing a nucleus surrounded by cytoplasm containing organelles commonly found in most cells. Notably, Nissl bodies, clusters of the rough endoplasmic reticulum and free ribosomes responsible for protein synthesis, are distinctive features of the neuronal cell body. As neurons age, aggregates of a brown pigment...

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Prevention of Further Absorption of Poison

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...

Preventive Healthcare Services

Preventive Healthcare Services

Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Coupling dead cell recognition to Fcγ receptors augments anticancer immunity.

Nature cancer·2026

Same author

Harnessing Notch Signaling to Enhance the Generation and Functionality of Human Conventional Type 1 Dendritic Cells for Cancer Immunotherapy Applications.

Cancer immunology research·2025

Same author

Human cDC1 enhance cytotoxic function of CD226+ terminally exhausted tumor-infiltrating lymphocytes.

Oncoimmunology·2025

Same author

Efficient generation of human dendritic cells from induced pluripotent stem cell by introducing a feeder-free expansion step for hematopoietic progenitors.

Journal of leukocyte biology·2025

Same author

Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer.

Nature immunology·2025

Same author

Exploring NK cell receptor dynamics in paediatric leukaemias: implications for immunotherapy and prognosis.

Clinical & translational immunology·2024

Search research articles

Related Experiment Video

Updated: Jan 23, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

Can Dendritic Cell Vaccination Prevent Leukemia Relapse?

Liam J O'Brien¹, Camille Guillerey², Kristen J Radford³

¹Mater Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia. liam.obrien@mater.uq.edu.au.

|June 26, 2019

Summary

Dendritic cell (DC) vaccination shows promise for leukemia treatment, overcoming immunosuppression and improving survival in Acute Myeloid Leukemia (AML). Further strategies aim to enhance DC function for better outcomes in leukemia patients.

Keywords:

CD141 CD1c dendritic cell immunotherapy leukemia moDC vaccination

More Related Videos

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

Published on: May 19, 2023

Related Experiment Videos

Last Updated: Jan 23, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

Published on: May 19, 2023

Area of Science:

* Immunology
* Hematology
* Oncology

Background:

* Leukemias are clonal disorders of immature leukocytes, often relapsing despite targeted therapies.
* Dendritic cell (DC) vaccination offers potential for long-lasting anti-tumor immunity but faces barriers like immunosuppression and disrupted hematopoiesis in leukemias.
* Cancer cells produce immunosuppressive factors hindering DC and T cell function, while leukemia disrupts the bone marrow microenvironment.

Purpose of the Study:

* To review the phenotype and function of DCs in leukemia.
* To explore strategies for harnessing DCs in leukemia patients.
* To discuss recent clinical successes and future directions for DC vaccination in AML and other leukemias.

Main Methods:

* Review of existing literature on DC biology in leukemia.
* Analysis of clinical trial data for DC vaccination in leukemia.
* Discussion of novel strategies to enhance DC function and anti-leukemia immunity.

Main Results:

* Recent clinical trials demonstrate extended survival for Acute Myeloid Leukemia (AML) patients using DC vaccination.
* Despite challenges, DC vaccination has shown safety and emerging efficacy in certain leukemia subtypes.
* Understanding DC function and the leukemia microenvironment is key to improving vaccine efficacy.

Conclusions:

* Dendritic cell vaccination is a promising immunotherapy for leukemia, particularly AML.
* Overcoming immunosuppression and enhancing DC function are critical for successful leukemia treatment.
* New strategies hold potential to improve prognosis for AML and other leukemias through enhanced DC-based immunotherapy.