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Updated: Jan 23, 2026

Preparation and Analysis of In Vitro Three Dimensional Breast Carcinoma Surrogates
Published on: May 9, 2016
Tolerability and surrogate efficacy parameters of a polymerized depot mixture pollen extracts without dilutional
Joaquín Quiralte1, María Angeles Lara2, Gemma Vanesa Sánchez3
1Hospital Universitario Virgen del Rocío, Allergology Department, Sevilla, Spain.
Abstract:
Aim: To evaluate tolerability of subcutaneous immunotherapy, in a polymerized mixture (Olea europaea/Phleum pratense) depot presentation. Patients & methods: A total of 47 poly-allergic patients received: an abbreviated schedule with three injections at weekly intervals or a cluster schedule with two administrations in 1 day. Both treatments continued with 3 monthly maintenance administrations. Results: Two systemic reactions, (4.3%). One grade 0 and one grade I. No local reactions. Immunoglobulin levels, increased significantly at final visit versus baseline in sIgG and sIgG4; in both schedules and allergens, no significant changes in specific immunoglobulin E levels were detected. Cutaneous reactivity at final visit decreased significantly. Conclusion: Both administration schedules with polymerized mixture of O. europaea/P. pratense, presented an excellent tolerability profile and induced preliminary efficacy changes.
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