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Oncolytic Measles Virotherapy and Opposition to Measles Vaccination

Stephen J Russell1, Dusica Babovic-Vuksanovic2, Alice Bexon3

  • 1Department of Molecular Medicine, Mayo Clinic, Rochester, MN; Division of Hematology, Mayo Clinic, Rochester, MN.

Mayo Clinic Proceedings
|June 26, 2019
PubMed

Insights

Measles vaccination is crucial for public health, despite misinformation linking it to autism. Measles infection does not protect against cancer; vaccination may enhance future cancer therapies.

Area of Science:

  • Immunology
  • Virology
  • Oncology

Background:

  • Declining vaccination rates have led to resurgent measles outbreaks.
  • Misinformation about measles vaccination and autism persists, lacking scientific evidence.
  • A new antivaccination argument claims measles immunity is protective against cancer.

Purpose of the Study:

  • To refute the claim that measles infection is protective against cancer.
  • To address the impact of vaccination on potential measles virus-based cancer therapies.

Main Methods:

  • Review of scientific literature on measles virus and cancer.
  • Analysis of the effects of pre-existing immunity on oncolytic measles virus therapy.

Main Results:

  • Measles infection is not protective against cancer.
  • Prior vaccination does not hinder, but may improve, the efficacy of measles virus as a cancer therapy.

Conclusions:

  • Measles vaccination is essential for maintaining population immunity and preventing outbreaks.
  • The claim that measles protects against cancer is scientifically unfounded.
  • Vaccination is compatible with and potentially beneficial for measles virus-based cancer treatments.

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