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Updated: Jan 23, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Mifepristone: An Uncommon Cause of Drug-Induced Liver Injury
Ishani Shah1, Tyler Putnam1, Evan Daugherty2
1Department of Internal Medicine, Creighton University St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Abstract:
Mifepristone is frequently used in large doses for management of Cushing's syndrome. This is a case of a 35-year-old woman with Cushing's syndrome, who presented with abdominal pain and jaundice. A month prior to admission, she had been started on a daily dose of 1,200 mg mifepristone. After evaluating for various other causes of liver injury, biopsy revealed cholestatic pattern of liver disease, likely associated with drug-induced hepatotoxicity. Mifepristone was discontinued and her symptoms resolved. We believe this is one of the first few reported cases of drug-induced liver injury (DILI) associated with mifepristone use.
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