Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Initiation of Translation02:33

Initiation of Translation

38.4K
Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
38.4K
Replication in Eukaryotes02:31

Replication in Eukaryotes

204.1K
Overview
204.1K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

18.7K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.7K
Eukaryotic RNA Polymerases00:58

Eukaryotic RNA Polymerases

26.8K
RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
All three eukaryotic RNAPs require specific transcription factors, of which the...
26.8K
Transcription Factors02:16

Transcription Factors

82.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.3K
What is Monogastric Digestion?01:50

What is Monogastric Digestion?

75.1K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
75.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Li-air chemistry inspired electrodialysis for direct lithium carbonate production from seawater.

Nature communications·2026
Same author

Policy synergies outweigh trade-offs for NH<sub>3</sub> and N<sub>2</sub>O co-control in China.

Nature food·2026
Same author

Effect of damming on phosphorus distribution and transformation in riparian zones along the bypass seepage pathway.

Journal of environmental management·2026
Same author

[Comparison of the Consistency and Application Value of Transabdominal Intestinal Ultrasound and Computed Tomography Enterography in the Diagnosis of Inflammatory Bowel Disease Complicatedwith Intestinal Stenosis].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2026
Same author

[Comparison of Imaging Efficacy and Patient Tolerability Between a Novel Cellulose-Based anda Conventional Starch-Based Oral Contrast Agent: A Prospective Randomized Controlled Trial].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2026
Same author

Mechanistic insights into the anti-metastatic effects of calycosin from Ruanjianhugan tablets on hepatocellular carcinoma <i>via</i> CHEK1 targeting: a network analysis.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology·2026

Related Experiment Video

Updated: Jan 23, 2026

Human Pancreatic Islet Isolation: Part I: Digestion and Collection of Pancreatic Tissue
11:54

Human Pancreatic Islet Isolation: Part I: Digestion and Collection of Pancreatic Tissue

Published on: May 26, 2009

20.0K

Eukaryotic initiation factor 5A2 and human digestive system neoplasms.

Qing-Bin Meng1, Jing-Jing Peng2, Zi-Wei Qu1

  • 1Department of Gastrointestinal Surgery, the First Hospital of Wuhan City, Wuhan 430022, Hubei Province, China.

World Journal of Gastrointestinal Oncology
|June 26, 2019
PubMed
Summary
This summary is machine-generated.

Eukaryotic initiation factor 5A2 (eIF5A2) is an oncogenic protein driving cancer progression, metastasis, and treatment resistance. Targeting eIF5A2 offers a promising strategy for cancer therapy and prognosis.

Keywords:
Acetylation modificationCancer therapeuticsDrug resistanceEukaryotic translation initiation factor 5A2Hypusine modification

More Related Videos

Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors
11:42

Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors

Published on: November 4, 2019

6.5K
Analysis of Translation Initiation During Stress Conditions by Polysome Profiling
10:59

Analysis of Translation Initiation During Stress Conditions by Polysome Profiling

Published on: May 19, 2014

18.8K

Related Experiment Videos

Last Updated: Jan 23, 2026

Human Pancreatic Islet Isolation: Part I: Digestion and Collection of Pancreatic Tissue
11:54

Human Pancreatic Islet Isolation: Part I: Digestion and Collection of Pancreatic Tissue

Published on: May 26, 2009

20.0K
Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors
11:42

Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors

Published on: November 4, 2019

6.5K
Analysis of Translation Initiation During Stress Conditions by Polysome Profiling
10:59

Analysis of Translation Initiation During Stress Conditions by Polysome Profiling

Published on: May 19, 2014

18.8K

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Eukaryotic initiation factor 5A2 (eIF5A2) is a key oncogenic protein implicated in various human cancers.
  • Overexpression and gene amplification of EIF5A2 are frequently observed in malignant tumors.
  • eIF5A2 plays a critical role in tumor initiation, growth, metastasis, and therapeutic resistance.

Purpose of the Study:

  • To review the expression, localization, modifications, and functions of eIF5A2 in cancer.
  • To explore the clinical applications of eIF5A2 as a biomarker and therapeutic target.
  • To highlight eIF5A2's role in digestive system neoplasms.

Main Methods:

  • Literature review of studies on eIF5A2 in human cancers.
  • Analysis of eIF5A2 expression, localization, and post-translational modifications.
  • Examination of eIF5A2's biochemical functions and regulatory networks.

Main Results:

  • eIF5A2 promotes tumor formation, cell growth, metastasis, and treatment resistance.
  • Mechanisms include inducing epithelial-mesenchymal transition, cytoskeletal rearrangement, angiogenesis, and metabolic reprogramming.
  • eIF5A2 expression correlates with poor prognosis, advanced stage, and metastasis.

Conclusions:

  • eIF5A2 is crucial for tumor development and maintenance, but not normal tissue homeostasis.
  • eIF5A2 serves as a valuable prognostic biomarker and a potential molecular target for anticancer therapies.
  • Further research into eIF5A2's role, particularly in digestive cancers, is warranted for clinical applications.