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Eukaryotic initiation factor 5A2 and human digestive system neoplasms

Qing-Bin Meng1, Jing-Jing Peng2, Zi-Wei Qu1

  • 1Department of Gastrointestinal Surgery, the First Hospital of Wuhan City, Wuhan 430022, Hubei Province, China.

World Journal of Gastrointestinal Oncology
|June 26, 2019
PubMed

Insights

Eukaryotic initiation factor 5A2 (eIF5A2) is an oncogenic protein driving cancer progression, metastasis, and treatment resistance. Targeting eIF5A2 offers a promising strategy for cancer therapy and prognosis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Eukaryotic initiation factor 5A2 (eIF5A2) is a key oncogenic protein implicated in various human cancers.
  • Overexpression and gene amplification of EIF5A2 are frequently observed in malignant tumors.
  • eIF5A2 plays a critical role in tumor initiation, growth, metastasis, and therapeutic resistance.

Purpose of the Study:

  • To review the expression, localization, modifications, and functions of eIF5A2 in cancer.
  • To explore the clinical applications of eIF5A2 as a biomarker and therapeutic target.
  • To highlight eIF5A2's role in digestive system neoplasms.

Main Methods:

  • Literature review of studies on eIF5A2 in human cancers.
  • Analysis of eIF5A2 expression, localization, and post-translational modifications.
  • Examination of eIF5A2's biochemical functions and regulatory networks.

Main Results:

  • eIF5A2 promotes tumor formation, cell growth, metastasis, and treatment resistance.
  • Mechanisms include inducing epithelial-mesenchymal transition, cytoskeletal rearrangement, angiogenesis, and metabolic reprogramming.
  • eIF5A2 expression correlates with poor prognosis, advanced stage, and metastasis.

Conclusions:

  • eIF5A2 is crucial for tumor development and maintenance, but not normal tissue homeostasis.
  • eIF5A2 serves as a valuable prognostic biomarker and a potential molecular target for anticancer therapies.
  • Further research into eIF5A2's role, particularly in digestive cancers, is warranted for clinical applications.
Keywords:
Acetylation modificationCancer therapeuticsDrug resistanceEukaryotic translation initiation factor 5A2Hypusine modification

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