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Updated: Jan 23, 2026
High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
Published on: March 3, 2015
Post-transcriptional control of immune responses and its potential application
Masanori Yoshinaga1, Osamu Takeuchi1
1Department of Medical Chemistry Graduate School of Medicine Kyoto University Kyoto Japan.
Abstract:
Inflammation is the host response against stresses such as infection. Although the inflammation process is required for the elimination of pathogens, uncontrolled inflammation leads to tissue destruction and inflammatory diseases. To avoid this, the inflammatory response is tightly controlled by multiple layers of regulation. Post-transcriptional control of inflammatory mRNAs is increasingly understood to perform critical roles in this process. This is mediated primarily by a set of RNA binding proteins (RBPs) including tristetraprolin, Roquin and Regnase-1, and RNA methylases. These key regulators coordinate the inflammatory response by modulating mRNA pools in both immune and local nonimmune cells. In this review, we provide an overview of the post-transcriptional coordination of immune responses in various tissues and discuss how RBP-mediated regulation of inflammation may be harnessed as a potential class of treatments for inflammatory diseases.
Insights
Inflammation control relies on post-transcriptional regulation of inflammatory messenger RNAs (mRNAs). RNA binding proteins (RBPs) coordinate immune responses, offering potential therapeutic targets for inflammatory diseases.
Area of Science:
- Immunology
- Molecular Biology
- Genetics
Background:
- Inflammation is a vital host defense mechanism against pathogens.
- Uncontrolled inflammation causes tissue damage and inflammatory diseases.
- Tight regulation of the inflammatory response is crucial for maintaining homeostasis.
Purpose of the Study:
- To review the critical roles of post-transcriptional control in regulating inflammatory responses.
- To highlight the function of RNA binding proteins (RBPs) in immune and non-immune cells.
- To explore the therapeutic potential of RBP-mediated inflammation control.
Main Methods:
- Literature review focusing on post-transcriptional regulation of inflammatory mRNAs.
- Analysis of the roles of key RNA binding proteins (RBPs) such as tristetraprolin, Roquin, and Regnase-1.
- Examination of how these regulators modulate mRNA pools in cellular contexts.
Main Results:
- Post-transcriptional control, mediated by RBPs and RNA methylases, is essential for regulating inflammation.
- RBPs coordinate inflammatory responses in both immune and non-immune cells across various tissues.
- Dysregulation of these RBPs is implicated in the pathogenesis of inflammatory diseases.
Conclusions:
- Post-transcriptional regulation by RBPs is a key mechanism for controlling inflammation.
- Targeting RBP-mediated pathways presents a promising strategy for developing novel anti-inflammatory therapies.
- Further research into RBP functions could unlock new treatments for inflammatory conditions.
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