Related Experiment Video

Updated: Jan 23, 2026

A Melanoma Patient-Derived Xenograft Model
07:07

A Melanoma Patient-Derived Xenograft Model

Published on: May 20, 2019

13.1K

Patient-derived xenograft models to optimize kidney cancer therapies

Avi Patel1, Sarah Cohen1, Ravan Moret1

  • 1UQ-Ochsner Clinical School, Institute for Translational Research, Ochsner Clinic Foundation, New Orleans, LA, USA.

Translational Andrology and Urology
|June 26, 2019
PubMed

Insights

This review explores mouse xenograft models for screening renal cell carcinoma (RCC) treatments. Patient-derived orthotopic xenografts show promise for identifying effective therapies against this deadly kidney cancer.

Area of Science:

  • Oncology
  • Translational Medicine

Background:

  • Renal cell carcinoma (RCC) is a common adult kidney cancer with high metastatic potential.
  • Metastatic RCC presents a significant challenge, with poor survival rates due to treatment resistance.

Purpose of the Study:

  • To review preclinical mouse xenograft models for screening renal cell carcinoma (RCC) treatments.
  • To discuss the advantages and disadvantages of various models, particularly patient-derived orthotopic xenografts (PDX).

Main Methods:

  • Review of existing literature on mouse xenograft models for RCC.
  • Focus on patient-derived orthotopic xenograft (PDX) models for treatment screening.

Main Results:

  • Various mouse xenograft models exist for RCC treatment screening.
  • PDX models offer a promising approach for evaluating therapeutic options.

Conclusions:

  • Preclinical models, especially PDX, are crucial for identifying optimal therapies for individual RCC patients.
  • Further research into these models can improve treatment strategies for advanced renal cancer.
Keywords:
Orthotopicpatient-derived xenograft (PDX)renal cell carcinoma (RCC)

More Related Videos

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

14.3K
Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines08:42

Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines

Published on: July 19, 2019

10.7K

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.7K
Modeling in Therapy01:26

Modeling in Therapy

Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
395
Kidney Structure01:45

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
75.0K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.4K
Optimal Foraging00:48

Optimal Foraging

How animals obtain and eat their food is called foraging behavior. Foraging can include searching for plants and hunting for prey and depends on the species and environment.
13.7K