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Chronic Kidney Disease II: Clinical Manifestations01:24

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Chronic Kidney Disease I: Introduction01:25

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Related Experiment Video

Updated: Jan 23, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Chronic kidney disease after nephrectomy: a clinically-significant entity?

Robert J Ellis1

  • 1Centre for Kidney Disease Research, University of Queensland, and Princess Alexandra Hospital, Brisbane, Australia.

Translational Andrology and Urology
|June 26, 2019
PubMed
Summary

Kidney cancer surgery can reduce kidney function, potentially causing chronic kidney disease (CKD). This study argues that CKD significantly increases cardiovascular and mortality risks, regardless of its cause.

Keywords:
Nephrectomychronic kidney disease (CKD)estimated glomerular filtration ratekidney cancerrenal cell carcinoma

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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Area of Science:

  • Nephrology
  • Oncology
  • Urology

Background:

  • Kidney cancer is a significant global health concern, with surgery being the primary treatment.
  • Nephrectomy, a common surgical procedure for kidney cancer, can impair kidney function.
  • The clinical significance of chronic kidney disease (CKD) following nephrectomy is debated.

Purpose of the Study:

  • To argue that chronic kidney disease (CKD) resulting from kidney surgery is clinically significant.
  • To highlight the increased risks associated with reduced glomerular filtration rate (GFR).

Main Methods:

  • Literature review and critical analysis of existing studies on nephrectomy and CKD.
  • Discussion of the established links between reduced GFR and adverse health outcomes.

Main Results:

  • Surgical removal of kidney tissue leads to decreased glomerular filtration rate (GFR).
  • Reduced GFR is independently associated with elevated cardiovascular disease (CVD) risk.
  • Lower GFR is also linked to increased overall mortality.

Conclusions:

  • Chronic kidney disease (CKD) following kidney cancer surgery is of significant clinical importance.
  • The increased cardiovascular and mortality risks associated with reduced GFR underscore the clinical relevance of CKD, irrespective of its underlying cause.